Beilstein J. Org. Chem.2018,14, 1668–1692, doi:10.3762/bjoc.14.143
, hemithioacetal, various thioesters, thiocarbamate and isothiocyanate. This review article focuses on β-hydroxysulfides and analogs; their presence in natural products, general protocols for their synthesis, and examples of their application in target oriented synthesis.
Keywords: alkene thiofunctionalization
; epoxide thiolysis; β-hydroxysulfides; sulfur-containing natural products; Review
1. Introduction
Organosulfur compounds are widely distributed in nature, with marine organisms being the richest sources of these, since sulfur, as the sulfate ion, is the second most abundant anion in sea water after
fascinating biosynthesis of sulfur-containing secondary metabolites can be found in a recent review by Hertweck and co-workers [9].
2. β-Hydroxysulfidesβ-Hydroxysulfides, often in disguised form, comprise a significant segment of sulfur-containing natural products, with a few examples shown in Figure 2
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Graphical Abstract
Figure 1:
Some sulfur-containing natural products.